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ADHD Sense

ADHD is a neuro-inflammatory issue with an imbalance between oxidants and antioxidants. Inflammation in the brain causes brain fog, fatigue and prevents neurotransmitters from working properly
Role of Oxidative Stress and Neuroinflammation in Attention-Deficit/Hyperactivity Disorder – PMC

Antioxidants can be taken to reduce oxidative stress eg Vitamin E, Resveratrol, Vitamin C, Coenzyme Q10. High strength Omega 3 can be taken to reduce inflammation. Vitamin E prevents the oxidation of fatty acids and should be taken alongside omega 3 to protect brain fatty acids.
https://omega3galil.com/wp-content/uploads/2016/09/ADHD-treatment-with-omega-3-and-vitamin-e-ISSFAL-2016.pdf

Malondialdehyde levels in adult attention-deficit hyperactivity disorder this study demonstrates increased oxidative stress in ADHD.

The thyroid connection – the ‘normal’ range of thyroid stimulating hormone (TSH) is a continuum with optimal function in the middle of the range. As the TSH number moves further from the middle of the range, symptoms may develop but clinicians do not take action as the result is still in the ‘normal’ range. Thyroid hormones correlate with ADHD symptoms. Thyroid hormones affect the release of neurotransmitters. Thyroid hormone affects processes such as myelination, cell migration and differentiation, synaptogenesis, dendrite structure, transcriptional regulation, and synaptic plasticity. Optimise thyroid hormones by ensuring sufficient iodine, selenium, Vitamin A, zinc, copper, b vitamins

In one study it was found that 71% of children with ADHD had Iodine deficiency. Evaluation of Iodine Deficiency in Children with Attention Deficit/Hyperactivity Disorder – PMC

In ongoing iodine deficiency there is a shift towards more triiodothyronine (T3) thyroid hormone and less thyroxine (T4) thyroid hormone. Brain tissue cannot use T3 as well as T4, the brain will struggle to respond in iodine deficiency. Iodine also has antioxidant effects.

Vitamin B12 https://pmc.ncbi.nlm.nih.gov/articles/PMC11048887/ The results showed significantly increased Homocysteine levels and decreased vitamin B12 levels in ADHD patients compared to Healthy controls

Magnesium https://www.sciencedirect.com/science/article/abs/pii/S0165178118318456 The evidence from this meta-analysis supports the theory that an inverse relationship between serum magnesium deficiency and ADHD exists.

Vitamin D https://www.sciencedirect.com/science/article/abs/pii/S1876382018301975 Primary evidence has shown that increase in the concentration of 25(OH) vitamin D serum decreases ADHD symptoms and vice versa. Vitamin D has anti-inflammatory effects.

Histamine and mast cells activation can worsen inflammation. Vitamin C reduces the release of histamine. Zinc inhibits the release of histamine.

Omega 3 https://pmc.ncbi.nlm.nih.gov/articles/PMC4968854/ There is evidence that a ω-3 PUFA treatment has a positive effect on ADHD.

Zinc https://pubmed.ncbi.nlm.nih.gov/14687872/ zinc improves symptoms of ADHD

Gut bacteria make neurotransmitters which travel to the brain via the gut brain axis. Therefore supplement with probiotics. Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications – PMC

Pesticides exposure from food. Pesticides act as neurotoxins to insects. There is low level toxicity to humans in the form of neurological dysfunction. Try to eat organic or rinse fruit and vegetables well

https://pmc.ncbi.nlm.nih.gov/articles/PMC4415012/ Epidemiologic data reveal that children aged 6–15 with detectable levels of pyrethroid metabolites in their urine were more than twice as likely to be diagnosed with ADHD.

Anecdotal reports of benefits of electrolytes or rehydration salts added to water seems plausible due to nervous transmission requiring electrolytes and tap water processing removes minerals.

Exercise improves neuroplasticity (the brains ability to rewire and evolve). The kynurenine pathway is affected by exercise and exercise reduces the toxic metabolites/breakdown products. This can reduce accumulation of toxic compounds in the brain.